List of diseases covered by
Amyotrophic Lateral Sclerosis NGS panel

Gene Condition
ALS2 Amyotrophic lateral sclerosis 2, juvenile;
Primary lateral sclerosis, juvenile;
Spastic paralysis, infantile onset ascending
ANG Amyotrophic lateral sclerosis 9
CHCHD10 Frontotemporal dementia and/or amyotrophic
lateral sclerosis 2; Myopathy, isolated mitochondrial, autosomal dominant;
Spinal muscular atrophy, Jokela type
CHMP2B Amyotrophic lateral sclerosis 17;
Dementia, familial, nonspecific
ERBB4 Amyotrophic lateral sclerosis 19
FIG4 Amyotrophic lateral sclerosis 11;
Charcot-Marie-Tooth disease, type 4J; Yunis-Varon syndrome
FUS Amyotrophic lateral sclerosis 6,
with or without frontotemporal dementia; Essential tremor, hereditary, 4
MATR3 Amyotrophic lateral sclerosis 21
OPTN Amyotrophic lateral sclerosis 12
PFN1 Amyotrophic lateral sclerosis 18
SETX Amyotrophic lateral sclerosis 4, juvenile;
Spinocerebellar ataxia, autosomal recessive 1
SIGMAR1 Amyotrophic lateral sclerosis 16, juvenile;
Spinal muscular atrophy, distal, autosomal recessive, 2
SOD1 Amyotrophic lateral sclerosis 1
SPART Troyer syndrome
SPG11 Amyotrophic lateral sclerosis 5, juvenile;
Charcot-Marie-Tooth disease, axonal, type 2X;
Spastic paraplegia 11, autosomal recessive
SQSTM1 Frontotemporal dementia and/or
amyotrophic lateral sclerosis 3;
Myopathy, distal, with rimmed vacuoles;
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset;
Paget disease of bone 3
TARDBP Amyotrophic lateral sclerosis 10,
with or without FTD; Frontotemporal lobar degeneration, TARDBP-related
TBK1 Frontotemporal dementia and/or
amyotrophic lateral sclerosis 4;
TUBA4A Amyotrophic lateral sclerosis 22
with or without frontotemporal dementia
UBQLN2 Amyotrophic lateral sclerosis 15,
with or without frontotemporal dementia
VAPB Amyotrophic lateral sclerosis 8;
Spinal muscular atrophy, late-onset, Finkel type
VCP Amyotrophic lateral sclerosis 14,
with or without frontotemporal dementia;
Charcot-Marie-Tooth disease, type 2Y;
Inclusion body myopathy with early-onset Paget disease and
frontotemporal dementia 1