{"id":20626,"date":"2017-10-16T09:02:04","date_gmt":"2017-10-16T06:02:04","guid":{"rendered":"http:\/\/www.asperbio.com\/?page_id=20626"},"modified":"2020-06-01T12:28:08","modified_gmt":"2020-06-01T09:28:08","slug":"huperlipoproteineemia-tuup-v","status":"publish","type":"page","link":"https:\/\/www.asperbio.com\/et\/asper-cardiogenetics-testid\/huperlipoproteineemia-tuup-v\/","title":{"rendered":"H\u00fcperlipoproteineemia, t\u00fc\u00fcp V"},"content":{"rendered":"

T\u00fc\u00fcp V h\u00fcperlipoproteineemiaga seotud\u00a0APOA5<\/i>\u00a0geeni sekveneerimine<\/h2>\n
\n\n\n\n
Geenid:<\/strong><\/td>\nAPOA5<\/i><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Metoodika:<\/strong><\/td>\nKodeeriva piirkonna sekveneerimine (Sanger)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Testi valmimisaeg:<\/strong><\/td>\n2-4 n\u00e4dalat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
N\u00f5uded proovi-materjalile:<\/strong><\/td>\n2-4 ml t\u00e4isverd antikoagulandiga EDTA (lilla korgiga katsuti)<\/p>\n

500 ng DNA-d elueerituna TE, AE puhvris v\u00f5i steriilses vees, kontsentratsiooniga 100-250 ng\/\u00b5l
\nDNA saata toatemperatuuril v\u00f5i k\u00fclmutatuna. A260\/A280 suhe peaks olema 1.8-2.0. DNA peab agaroosgeelis pikkusmarkeri juuresolekul olema detekteeritav \u00fche tervikliku b\u00e4ndina.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n\n\n\n
Tellimine:<\/strong><\/td>\nProovimaterjal saata koos saatekirjaga<\/a><\/strong><\/span> Asper Biogene laborisse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n<\/div>\n

N\u00e4idustused geenitesti tegemiseks<\/strong>:
\n1. Kliinilise diagnoosi kinnitamine
\n2. Pereliikmete testimine
\n3. Iseloomulike s\u00fcmptomite, nagu ksantoomid, esinemine
\n4. Geneetiline n\u00f5ustamine<\/p>\n

T\u00fc\u00fcp V h\u00fcperlipoproteineemiat<\/strong> iseloomustab v\u00e4ga v\u00e4ikese tihedusega lipoproteiinide\u00a0ja k\u00fclomikronite taseme t\u00f5us ning v\u00e4ikese ja k\u00f5rge tihedusega lipoproteiinide taseme langus plasmas paastuj\u00e4rgselt m\u00f5\u00f5detuna. Haigus h\u00f5lmab v\u00e4ga erinevaid patoloogilisi seisundeid, nii kaasas\u00fcndinud kui omandatud aspekte. Iseloomulik on m\u00f5\u00f5dukas kuni m\u00e4rkimisv\u00e4\u00e4rne h\u00fcpertrigl\u00fctserideemia. S\u00fcmptomiteks on k\u00f5huvalu ja l\u00f6\u00f6belised ksantoomid. H\u00fcperlipideemia<\/strong> t\u00fcsistuseks v\u00f5ib sageli olla pankreatiit.<\/p>\n

T\u00fc\u00fcp V h\u00fcperlipoproteineemia v\u00f5ib olla p\u00f5hjustatud mutatsioonidest APOA5 geenis<\/strong>, mis v\u00f5ivad p\u00e4randuda autosoom-dominantsel v\u00f5i autosoom-retsessiivsel teel.<\/p>","protected":false},"excerpt":{"rendered":"

T\u00fc\u00fcp V h\u00fcperlipoproteineemiaga seotud\u00a0APOA5\u00a0geeni sekveneerimine Geenid: APOA5 Metoodika: Kodeeriva piirkonna sekveneerimine (Sanger) Testi valmimisaeg: 2-4 n\u00e4dalat N\u00f5uded proovi-materjalile: 2-4 ml t\u00e4isverd antikoagulandiga EDTA (lilla korgiga katsuti) 500 ng DNA-d elueerituna TE, AE puhvris v\u00f5i steriilses vees, kontsentratsiooniga 100-250 ng\/\u00b5l DNA saata toatemperatuuril v\u00f5i k\u00fclmutatuna. A260\/A280 suhe peaks olema 1.8-2.0. DNA peab agaroosgeelis pikkusmarkeri juuresolekul olema […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":14537,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-20626","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/20626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/comments?post=20626"}],"version-history":[{"count":3,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/20626\/revisions"}],"predecessor-version":[{"id":25873,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/20626\/revisions\/25873"}],"up":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/14537"}],"wp:attachment":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/media?parent=20626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}