{"id":20601,"date":"2017-10-13T16:05:02","date_gmt":"2017-10-13T13:05:02","guid":{"rendered":"http:\/\/www.asperbio.com\/?page_id=20601"},"modified":"2023-08-25T14:08:04","modified_gmt":"2023-08-25T11:08:04","slug":"arutmia","status":"publish","type":"page","link":"https:\/\/www.asperbio.com\/et\/asper-cardiogenetics-testid\/arutmia\/","title":{"rendered":"Ar\u00fctmia"},"content":{"rendered":"

Ar\u00fctmiaga seotud geenide sekveneerimine<\/h2>\n
\n\n\n\n
Geenid:<\/strong><\/td>\nABCC9, AKAP9, ANK2, CACNA1C, CACNA2D1, CACNB2, CASQ2, CAV3, DES, DSC2, DSG2, DSP, FLNC, GJA5, GPD1L, HCN4, JUP, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNE5, KCNH2, KCNJ2, KCNJ8, KCNQ1, LMNA, NEBL, NKX2-5, NPPA, PITX2, PKP2, PLN, PRDM16, PRKAG2, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SNTA1, TGFB3, TMEM43<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Metoodika:<\/strong><\/td>\nKodeeriva piirkonna sekveneerimine (NGS).
\nKoopiaarvu muutuste bioinformaatiline anal\u00fc\u00fcs (CNV). CNV leidude kinnitamine teise meetodiga toimub lisaanal\u00fc\u00fcsina, vastavalt hinnakirjale.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Testi valmimisaeg:<\/strong><\/td>\n6-9 n\u00e4dalat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
N\u00f5uded proovi-materjalile:<\/strong><\/td>\n2-4 ml t\u00e4isverd antikoagulandiga EDTA (lilla korgiga katsuti)<\/p>\n

1 \u00b5g DNA-d elueerituna TE, AE puhvris v\u00f5i steriilses vees, kontsentratsiooniga 100-250 ng\/\u00b5l
\nDNA saata toatemperatuuril v\u00f5i k\u00fclmutatuna. A260\/A280 suhe peaks olema 1.8-2.0. DNA peab agaroosgeelis pikkusmarkeri juuresolekul olema detekteeritav \u00fche tervikliku b\u00e4ndina.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n\n\n\n
Tellimine:<\/strong><\/td>\nProovimaterjal saata koos saatekirjaga<\/a><\/strong><\/span> Asper Biogene laborisse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n<\/div>\n

N\u00e4idustused geenitesti tegemiseks:<\/strong><\/p>\n

    \n
  1. Kliinilise diagnoosi kinnitamine<\/li>\n
  2. Ebaselge ar\u00fctmiaga ja\/v\u00f5i s\u00fcdame seiskumise l\u00e4bi teinud patsientide testimine<\/li>\n
  3. Patsiendi pereliikmete testimine<\/li>\n
  4. Geneetiline n\u00f5ustamine<\/li>\n<\/ol>\n

    S\u00fcdame r\u00fctmih\u00e4ired ehk ar\u00fctmiad<\/strong> on haiguste grupp, mida iseloomustab ebaregulaarne, liiga aeglane v\u00f5i liiga kiire s\u00fcdamer\u00fctm. R\u00fctmih\u00e4ireid jaotatakse j\u00e4rgmiselt: brad\u00fckardiad<\/strong>, ektoopiaar\u00fctmiad<\/strong>, supraventrikulaarsed<\/strong> ja ventrikulaarsed ar\u00fctmiad<\/strong>. Supraventrikulaarsed ar\u00fctmiad h\u00f5lmavad kodade virvendusar\u00fctmiat, kodade laperdusar\u00fctmiat ja paroks\u00fcsmaalset supraventrikulaarset tahh\u00fckardiat. Ventrikulaarsed ar\u00fctmiad on ventrikulaarne fibrillatsioon ja ventrikulaarne tahh\u00fckardia. Ektoopiaar\u00fctmiad haaravad kodade, vatsakeste ja atrioventrikulaar\u00fchenduse enneaegset depolarisatsiooni.<\/p>\n

    Ar\u00fctmiate p\u00f5hjuseks on s\u00fcdame elektrilise juhtes\u00fcsteemi h\u00e4ire.\u00a0K\u00f5ik r\u00fctmih\u00e4ired pole ohtlikud, kuid raskematel juhtudel v\u00f5ivad r\u00fctmih\u00e4ired p\u00f5hjustada eluohtlikke komplikatsioone nagu infarkt, s\u00fcdamepuudulikkus v\u00f5i s\u00fcdame seiskumine.<\/p>","protected":false},"excerpt":{"rendered":"

    Ar\u00fctmiaga seotud geenide sekveneerimine Geenid: ABCC9, AKAP9, ANK2, CACNA1C, CACNA2D1, CACNB2, CASQ2, CAV3, DES, DSC2, DSG2, DSP, FLNC, GJA5, GPD1L, HCN4, JUP, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNE5, KCNH2, KCNJ2, KCNJ8, KCNQ1, LMNA, NEBL, NKX2-5, NPPA, PITX2, PKP2, PLN, PRDM16, PRKAG2, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SNTA1, TGFB3, TMEM43 Metoodika: Kodeeriva piirkonna sekveneerimine (NGS). […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":14537,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-20601","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t