{"id":12043,"date":"2015-11-10T12:01:48","date_gmt":"2015-11-10T12:01:48","guid":{"rendered":"http:\/\/www.asperbio.com\/?page_id=12043"},"modified":"2018-10-29T14:22:38","modified_gmt":"2018-10-29T12:22:38","slug":"mikrosatelliitide-ebastabiilsus","status":"publish","type":"page","link":"https:\/\/www.asperbio.com\/et\/asper-oncogenetics-testid\/mikrosatelliitide-ebastabiilsus\/","title":{"rendered":"Mikrosatelliitide ebastabiilsus"},"content":{"rendered":"<h2 style=\"padding-left: 5px;\"><span style=\"color: #97c46d;\">Mikrosatelliitide ebastabiilsuse anal\u00fc\u00fcs<\/span><\/h2>\n<div class=\"sm_post_content\" style=\"background: url('https:\/\/www.asperbio.com\/wp-content\/uploads\/t-roheline.png') repeat-y; padding-left: 40px;\">\n<table class=\"table no-border no-margin\" style=\"width: 476px;\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 111.484375px;\"><strong>Markerite arv:<\/strong><\/td>\n<td style=\"width: 358.53125px;\">7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"color: #97c46d; background-color: #97c46d; height: 2px; border: none; width: 100%;\" \/>\n<table class=\"table no-border no-margin\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"110\"><strong>Metoodika:<\/strong><\/td>\n<td>Fragmentanal\u00fc\u00fcs<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"color: #97c46d; background-color: #97c46d; height: 2px; border: none; width: 100%;\" \/>\n<table class=\"table no-border no-margin\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"110\"><strong>Testi valmimisaeg:<\/strong><\/td>\n<td>3\u00a0n\u00e4dalat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"color: #97c46d; background-color: #97c46d; height: 2px; border: none; width: 100%;\" \/>\n<table class=\"table no-border no-margin\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"110\"><strong>N\u00f5uded proovi-materjalile:<\/strong><\/td>\n<td>Formaliinis fikseeritud parafiinblokk kasvajakoega ja terve kude<\/p>\n<ul>\n<li>Parim kasvajakoe materjal on ravieelne biopsia<\/li>\n<li>Parim terve koe materjal on 2-4 ml t\u00e4isverd antikoagulandiga EDTA\u00a0(lilla korgiga katsuti)<\/li>\n<li>Kasvajakoega parafiinbloki s\u00e4ilitus- ja transpordi temperatuur v\u00f5iks olla vahemikus 20-25\u00b0C<\/li>\n<li>Testi tulemusi ei ole v\u00f5imalik v\u00e4ljastada, kui v\u00e4hirakkude osakaal on v\u00e4iksem kui\u00a02%, kasvajakoest eraldatud DNA kvaliteet on madal v\u00f5i DNA on fikseerimisprotsessi tulemusena liialt fragmenteerunud<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"color: #97c46d; background-color: #97c46d; height: 2px; border: none; width: 100%;\" \/>\n<table class=\"table no-border no-margin\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"110\"><strong>Tellimine:<\/strong><\/td>\n<td>Proovimaterjal saata koos <a href=\"https:\/\/www.asperbio.com\/wp-content\/uploads\/Asper-Oncogenetics-saatekiri.doc\"><span style=\"color: #97c46d;\"><strong>saatekirjaga<\/strong><\/span><\/a> Asper Biogene laborisse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"color: #97c46d; background-color: #97c46d; height: 2px; border: none; width: 100%;\" \/>\n<\/div>\n<p><strong>N\u00e4idustused geenitesti tegemiseks:<\/strong><\/p>\n<ol>\n<li>Kolorektaalv\u00e4hi v\u00f5i teiste Lynchi s\u00fcndroomi-seoseliste kasvajate\u00a0diagnoosiga patsientide testimiseks, hindamaks mutatsioonide esinemise t\u00f5en\u00e4osust DNA valepaardumise reparatsiooni s\u00fcsteemi <em>(mismatch repair)<\/em> geenides<\/li>\n<li>Haiguse prognoosi m\u00e4\u00e4ramiseks<\/li>\n<li>Geneetiline n\u00f5ustamine<\/li>\n<\/ol>\n<p>Mutatsioonide olemasolule MMR <em>(mismatch repair)\u00a0<\/em>geenides viitab ka mikrosatelliitide ebastabiilsuse <em>(MSI \u2013 microsatellite instability)<\/em> esinemine kasvajakoes. Mikrosatelliitide ebastabiilsus esineb ligikaudu 90% Lynchi s\u00fcndroomi juhtude korral. Patsiendid, kellel leitakse mikrosatelliitide ebastabiilsust, tuleks suunata edasistele geeniuuringutele.<\/p>\n<p>MSI testimiseks v\u00f5rreldakse omavahel sama indiviidi kasvajakoest eraldatud DNA mikrosatelliitide regioone ja tervest koest eraldatud DNA vastavaid regioone.<\/p>","protected":false},"excerpt":{"rendered":"<p>Mikrosatelliitide ebastabiilsuse anal\u00fc\u00fcs Markerite arv: 7 Metoodika: Fragmentanal\u00fc\u00fcs Testi valmimisaeg: 3\u00a0n\u00e4dalat N\u00f5uded proovi-materjalile: Formaliinis fikseeritud parafiinblokk kasvajakoega ja terve kude Parim kasvajakoe materjal on ravieelne biopsia Parim terve koe materjal on 2-4 ml t\u00e4isverd antikoagulandiga EDTA\u00a0(lilla korgiga katsuti) Kasvajakoega parafiinbloki s\u00e4ilitus- ja transpordi temperatuur v\u00f5iks olla vahemikus 20-25\u00b0C Testi tulemusi ei ole v\u00f5imalik v\u00e4ljastada, kui [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":16918,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-12043","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/12043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/comments?post=12043"}],"version-history":[{"count":3,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/12043\/revisions"}],"predecessor-version":[{"id":22996,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/12043\/revisions\/22996"}],"up":[{"embeddable":true,"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/pages\/16918"}],"wp:attachment":[{"href":"https:\/\/www.asperbio.com\/et\/wp-json\/wp\/v2\/media?parent=12043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}