{"id":11991,"date":"2015-11-06T14:50:43","date_gmt":"2015-11-06T14:50:43","guid":{"rendered":"http:\/\/www.asperbio.com\/?page_id=11991"},"modified":"2023-09-22T19:26:28","modified_gmt":"2023-09-22T16:26:28","slug":"11991-2","status":"publish","type":"page","link":"https:\/\/www.asperbio.com\/et\/asper-oncogenetics-testid\/11991-2\/","title":{"rendered":"P\u00e4riliku v\u00e4hi eelsoodumuse m\u00e4\u00e4ramine"},"content":{"rendered":"

P\u00e4riliku v\u00e4hi eelsoodumusega
\nseotud geenide sekveneerimine<\/span><\/h2>\n
\n\n\n\n
Geenid:<\/strong><\/td>\nAIP, ALK, APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, BUB1B, CDC73, CDH1, CDK4, CDKN1C, CDKN2A, CEBPA, CEP57, CHEK2, CYLD, DDB2, DICER1, DIS3L2, EGFR, EPCAM, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, EZH2, FANCA, FANCB, FANCC, FANCD2 <\/em>(v.a. eksonid 15, 16), FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FH, FLCN, GATA2, GPC3, GREM1, HNF1A, HOXB13, HRAS, KIT, MAX, MEN1, MET, MITF, MLH1, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NSD1, NTHL1, PALB2, PHOX2B, POLD1, POLE, PRF1, PRKAR1A, PRSS1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RECQL4, RET, RHBDF2, RNF43, RUNX1, SBDS, SDHA, SDHAF2, SDHB, SDHC, SDHD, SLX4, SMAD4, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1, XPA, XPC, XRCC2<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Metoodika:<\/strong><\/td>\nKodeeriva piirkonna sekveneerimine (NGS).
\nKoopiaarvu muutuste bioinformaatiline anal\u00fc\u00fcs (CNV). CNV leidude kinnitamine teise meetodiga toimub lisaanal\u00fc\u00fcsina, vastavalt hinnakirjale.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
Testi valmimisaeg:<\/strong><\/td>\n6-9\u00a0n\u00e4dalat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n
N\u00f5uded proovi-materjalile:<\/strong><\/td>\n2-4 ml t\u00e4isverd antikoagulandiga EDTA (lilla korgiga katsuti)<\/p>\n

1 \u00b5g DNA-d elueerituna TE, AE puhvris v\u00f5i steriilses vees, kontsentratsiooniga 100-250 ng\/\u00b5l
\nDNA saata toatemperatuuril v\u00f5i k\u00fclmutatuna. A260\/A280 suhe peaks olema 1.8-2.0. DNA peab agaroosgeelis pikkusmarkeri juuresolekul olema detekteeritav \u00fche tervikliku b\u00e4ndina.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n\n\n\n
Tellimine:<\/strong><\/td>\nProovimaterjal saata koos saatekirjaga<\/strong><\/span><\/a> Asper Biogene laborisse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n<\/div>\n

N\u00e4idustused geenitesti tegemiseks:<\/strong><\/p>\n

    \n
  1. Noores eas avastatud v\u00e4higa patsientide testimine<\/li>\n
  2. Erinevate v\u00e4hi algkolletega patsientide testimine<\/li>\n
  3. Testimaks isikuid, kelle l\u00e4hisugulastel on avastatud v\u00e4hki<\/li>\n
  4. Geneetiline n\u00f5ustamine<\/li>\n<\/ol>\n

    V\u00e4hi eelsoodumuse m\u00e4\u00e4ramine<\/strong> on oluline v\u00e4hi varajaseks avastamiseks. Varakult avastatud v\u00e4hkkasvaja allub paremini ravile, mis on oluline faktor parema elulemuse tagamiseks. Testi tulemusi saab kasutada nii erinevate v\u00e4hiennetuse strateegiate elluviimisel ning see aitab patsientidel erinevaid v\u00e4higa seotud muutusi varem m\u00e4rgata. Tulemused on abiks ka arstidele, kes saavad patsiente vastuv\u00f5tul suunatumalt konsulteerida.<\/p>","protected":false},"excerpt":{"rendered":"

    P\u00e4riliku v\u00e4hi eelsoodumusega seotud geenide sekveneerimine Geenid: AIP, ALK, APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, BUB1B, CDC73, CDH1, CDK4, CDKN1C, CDKN2A, CEBPA, CEP57, CHEK2, CYLD, DDB2, DICER1, DIS3L2, EGFR, EPCAM, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, EZH2, FANCA, FANCB, FANCC, FANCD2 (v.a. eksonid 15, 16), FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FH, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":16918,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-11991","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t