Venous Thrombosis risk assessment – VT
The annual incidence of Venous Thrombosis ranges from approximately 1 to 3 per 1000 people. Venous Thrombosis events often occur when multiple risk factors, including genetic and environmental, are present simultaneously. Acquired risk factors of Venous Thrombosis are age, immobilization, surgery, trauma, malignancy, myeloproliferative disorders, obesity, pregnancy, postpartum period, hormone replacement therapy, or use of oral contraceptives. Genetic risk factors are related to a 30-80 fold higher risk for developing a thrombotic episode.
RFLP-based test of predisposing genetic factors of thrombosis are carried out for factor V Leiden, the prothrombin G20210A mutation, MTHFR C677T, and the A1298C mutation.
The evaluation of genetic risk factors for Venous Thrombosis allows for proper consultation and medication for patients with high genetic risk in order to avoid thrombotic episodes and to provide genetic counseling/testing for relatives. The test is available with diagnostic package service (includes DNA extraction, genotyping, interpretation, hard copy of the results report).
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